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| Nom | Annaïg LAN |
| Grade | |
| Equipe | |
| Adresse | CHU Pontchaillou – 2 rue Henri Le Guilloux – 35033 Rennes Cedex |
| Research topics and scientific objectives | Normal 21 false FR /* Style Definitions */ The intestinal mucosa, and more specifically the epithelium, plays a central role in intestinal homeostasis as an integrator of immune and luminal signals. Understanding the epithelial mechanisms of adaptation in response to environmental changes linked to diet is of crucial interest, with fundamental and applied implications for human health and nutrition. By combining experimental nutritional manipulations in mouse models and cellular studies, my research aims to understand the dietary repercussions, in particular of an excess of macronutrients (proteins and currently lipids) on the luminal environment (composition of the microbiota, production of bacterial metabolites) and their consequences on intestinal homeostasis, in particular in terms of immune responses, epithelial renewal and functions (barrier and absorption) linked to energy metabolism. My work focuses on understanding the cellular and molecular mechanisms involved in epithelial repair following an inflammatory episode (in the context of ulcerative colitis) and on the link between epithelial mitochondrial dysfunction and barrier function in obese patients, in order to reduce complications. In addition, by proposing to study the nutritional and nutraceutical potential of Breton macroalgae, the results of these projects currently under development will ultimately help to propose new treatments to restore intestinal homeostasis in different physiopathological conditions. |
| Education and main positions held | Normal 21 false FR /* Style Definitions */ PhD. In Biology : UMR 1253 INRA-Agrocampus Ouest, Rennes, France (2004-2007) Postdoctorate in gut immunology :Rowett Research Institute of Nutrition and Health, Aberdeen, Royaume-Uni (2007-2009): Associate Professor at AgroParisTech, UMR Physiologie de la Nutrition et du Comportement Alimentaire (2010-2018) and at NuMeCan, INSERM U1317, Equipe EXPRES (since 2018) |
| Current projects | Mitochondrial function in colonic epithelial repair. Mitochondrial dysfunction of intestinal epithelial cells and intestinal barrier function in diet-induced obesity. Potential of macroalgae as new sustainable food source |
| Selected publications | Normal 21 false FR /* Style Definitions */ Andriamihaja, M.; Lan, A.; Beaumont, M.; Grauso, M.; Gotteland, M.; Pastene, E.; Cires, M. J.; Carrasco-Pozo, C.; Tome, D.; Blachier, F. Proanthocyanidin-Containing Polyphenol Extracts from Fruits Prevent the Inhibitory Effect of Hydrogen Sulfide on Human Colonocyte Oxygen Consumption. Amino Acids 2018, 50 (6), 755–763. https://doi.org/10.1007/s00726-018-2558-y. Vidal-Lletjós, S.; Andriamihaja, M.; Blais, A.; Grauso, M.; Lepage, P.; Davila, A.-M.; Viel, R.; Gaudichon, C.; Leclerc, M.; Blachier, F.; Lan, A. Dietary Protein Intake Level Modulates Mucosal Healing and Mucosa-Adherent Microbiota in Mouse Model of Colitis. Nutrients 2019, 11 (3), 514. https://doi.org/10.3390/nu11030514. Blachier, F.; Beaumont, M.; Portune, K. J.; Steuer, N.; Lan, A.; Audebert, M.; Khodorova, N.; Andriamihaja, M.; Airinei, G.; Benamouzig, R.; Davila, A.-M.; Armand, L.; Rampelli, S.; Brigidi, P.; Tomé, D.; Claus, S. P.; Sanz, Y. High-Protein Diets for Weight Management: Interactions with the Intestinal Microbiota and Consequences for Gut Health. A Position Paper by the My New Gut Study Group. Clinical Nutrition 2019, 38 (3), 1012–1022. https://doi.org/10.1016/j.clnu.2018.09.016. Vidal-Lletjós, S.; Andriamihaja, M.; Blais, A.; Grauso, M.; Lepage, P.; Davila, A.-M.; Gaudichon, C.; Leclerc, M.; Blachier, F.; Lan, A. Mucosal Healing Progression after Acute Colitis in Mice. WJG 2019, 25 (27), 3572–3589. https://doi.org/10.3748/wjg.v25.i27.3572. Armand, L.; Andriamihaja, M.; Gellenoncourt, S.; Bitane, V.; Lan, A.; Blachier, F. In Vitro Impact of Amino Acid-Derived Bacterial Metabolites on Colonocyte Mitochondrial Activity, Oxidative Stress Response and DNA Integrity. Biochim Biophys Acta Gen Subj 2019, 1863 (8), 1292–1301. https://doi.org/10/gjx5fx. Grauso, M.; Lan, A.; Andriamihaja, M.; Bouillaud, F.; Blachier, F. Hyperosmolar Environment and Intestinal Epithelial Cells: Impact on Mitochondrial Oxygen Consumption, Proliferation, and Barrier Function in Vitro. Sci Rep 2019, 9 (1), 11360. https://doi.org/10.1038/s41598-019-47851-9. Hermier, D.; Lan, A.; Tellier, F.; Blais, A.; Culetto, M. G.; Mathé, V.; Bellec, Y.; Gissot, L.; Schmidely, P.; Faure, J.-D. Intestinal Availability and Metabolic Effects of Dietary Camelina Sphingolipids during the Metabolic Syndrome Onset in Mice. J. Agric. Food Chem. 2020, 68 (3), 788–798. https://doi.org/10.1021/acs.jafc.9b06829. Vasseur, P.; Dugelay, E.; Benamouzig, R.; Savoye, G.; Hercberg, S.; Touvier, M.; Hugot, J.-P.; Julia, C.; Lan, A.; Buscail, C. Dietary Zinc Intake and Inflammatory Bowel Disease in the French NutriNet-Santé Cohort. Am J Gastroenterol 2020, 115 (8), 1293–1297. https://doi.org/10/gjx5gr. Vidal-Lletjós, S.; Khodorova, N. V.; Piscuc, M.; Gaudichon, C.; Blachier, F.; Lan, A. Tissue-Specific Effect of Colitis on Protein Synthesis in Mice: Impact of the Dietary Protein Content. Eur J Nutr 2020. https://doi.org/10.1007/s00394-020-02365-3. Blachier, F.; Andriamihaja, M.; Larraufie, P.; Ahn, E.; Lan, A.; Kim, E. Production of Hydrogen Sulfide by the Intestinal Microbiota and Epithelial Cells and Consequences for the Colonic and Rectal Mucosa. Am J Physiol Gastrointest Liver Physiol 2021, 320 (2), G125–G135. https://doi.org/10/gjx5fw. Vasseur, P.; Dugelay, E.; Benamouzig, R.; Savoye, G.; Lan, A.; Srour, B.; Hercberg, S.; Touvier, M.; Hugot, J.-P.; Julia, C.; Buscail, C. Dietary Patterns, Ultra-Processed Food, and the Risk of Inflammatory Bowel Diseases in the NutriNet-Santé Cohort. Inflamm Bowel Dis 2021, 27 (1), 65–73. https://doi.org/10/gjx5gs. Guerbette, T.; Boudry, G.; Lan, A. Mitochondrial Function in Intestinal Epithelium Homeostasis and Modulation in Diet-Induced Obesity. Molecular Metabolism 2022, 63, 101546. https://doi.org/10.1016/j.molmet.2022.101546. Blais, A.; Lan, A.; Boluktas, A.; Grauso-Culetto, M.; Chaumontet, C.; Blachier, F.; Davila, A.-M. Lactoferrin Supplementation during Gestation and Lactation Is Efficient for Boosting Rat Pup Development. Nutrients 2022 14 (14), 2814. https://doi.org/10.3390/nu14142814. T. Guerbette, M. Beaumont, M. Andriamihaja, V. Ciesielski, J-B Perrin, R Janvier, G. Randuineau, P. Leroyer, O. Loréal, V. Rioux, G. Boudry and A. Lan. Diet-induced obesity in mice leads to mitochondrial dysfunction in colonocytes and overproduction by Desulfovibrionaceae of the complex IV inhibitor H2S. FASEB J. 2023 Apr;37(4):e22853. https://doi.org/10.1096/fj.202201971R. A. Blais, A. Lan, F. Blachier, R. Benamouzig, P. Jouet, A. Couvineau. Efficiency of Orexin-A on inflammatory flare and mucosal healing in experimental colitis: comparison with the anti-TNF alpha infliximab. Int J Mol Sci. 2023 May 31;24(11):9554. https://doi.org/10.3390/ijms24119554. A. Lan, T. Guerbette, M. Andriamihaja, B. Magnin, M. Bordet, PJ. Ferron, A. Burel, R. Viel, B. Fromenty, A. Corlu, F. Blachier, G. Bouguen. Mitochondrial remodeling and energy metabolism adaptations in colonic crypts during spontaneous epithelial repair after colitis induction in mice. Free Radic Biol Med. 2023 Jun 12;205:224-233. https://doi.org/10.1016/j.freeradbiomed.2023.06.007. |