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| Nom | David VAL-LAILLET |
| Grade | |
| Equipe | |
| Adresse | F-35590 Saint-Gilles, France |
| Téléphone | |
| Skills | • Neurosciences |
| Research topics and scientific objectives | • Understand the multisensory integration mechanisms as well as the cognitive and brain processes involved in the control of eating behaviours |
| Education and main positions held | • 01/2024: Senior Research Director (DR1) at INRAE. • 2023-now: Deputy Chief of the Human Nutrition (AlimH) Division at INRAE. • 2022-now: Deputy Director of the CRNH-Ouest (Centre de Recherche en Nutrition Humaine de l’Ouest). • 2022-now: Co-responsible for the EAT team of the NuMeCan Institute (Inrae/Inserm/Univ Rennes 1). • 2017-2021: Director of the UMR 1341 NuMeCan Inrae/Univ Rennes 1; Deputy Director of the NuMeCan Institute (Inrae, Inserm, Univ Rennes 1), France. • 01/2017: Research Director (DR2) at INRAE. • 2013-2017: Director of the ADNC research department. INRA, UR1341 ADNC, F-35590 St Gilles, France. • 2007-present: Research scientist (senior) in Behavioural Sciences and Neurosciences applied to Human Nutrition and Health. INRA, UR1341 ADNC, F-35590 St Gilles, France. • 2006-2007: Post-doctoral scientist in Behavioural Sciences and Neurosciences applied to Human Nutrition and Health. INRA, UMR1078 SENAH, F-35590 St Gilles, France. • 2005-2006: Research Fellow in Animal Behaviour and Welfare. Expert in charge of governmental reports on animal welfare. AAFC, Pacific Agrifood Research Centre, Agassiz, British Columbia V0M 1A0, Canada. • 2001-2004: Doctoral thesis in Life and Health Sciences. INRA, UMR6175 PRC, F-37380 Nouzilly, France – University François Rabelais, Tours, France. • 2000-2001: Master in Behavioural Biology. University of Paris XIII, France. |
| Current projects | CLINICAL STUDIES: • CEMOV: “Neurofeedback to improve the control of eating behavior in normal-weight volunteers with emotional overeating”. • CADOB: “Neurofeedback to improve the control of eating behavior in obese patients with food addiction”. • AddictO: Research collaboration CHU CORECT / Inrae – “Exploration of the neurocognitive processes involved in food addiction in obese patients: Towards the definition of innovative biomarkers for prevention and clinical practice”. • Hed-O-Shift: Priority Action of the INRA Human Nutrition Division – “Palatable foods and neural plasticity: The shift in reward and cognitive processes”.
PRECLINICAL STUDIES: • SMARTPILL: NIH-funded research collaboration project with Carnegie Mellon Institute, USA, “Preclinical validation in the pig model of an ingestible electronic device to modulate vagal and brain activity non-invasively”. • ACUPIG: Franco-Chinese research collaboration – “Description of the neurophysiological, behavioural, and brain responses to electroacupuncture in the minipig model: Targeting the gut-brain axis to fight agains obesity”. • SARCOPIG: Preclinical study – “A minipig model to study denutrition and sarcopenia”. • Industrial research collaboration: Inrae/Phodé – “Impact of functional food ingredients to the microbiote-gut-brain axis and behaviour responses in a pig model of chronic psychosocial stress.”
OTHER RESEARCH COLLABORATIONS (INRAE/CHU Rennes) IN THE CONTEXT OF SURGERY AND IMAGING: • A minipig model of hepatic transplantation to investigate innovative strategies of liver graft preservation: PHOENIX project funded by the European Union’s Horizon Europe Research and Innovation programme, “Nanomedicine for organ transplantation tolerance”; SEABELIVER project, industrial collaboration, “Exploration of the effectiveness of a regulated necrosis inhibitor in a pig model of liver surgery and transplantation”. • A minipig model of uterine transplantation. • Development of fMRI paradigm to evaluate the cortical stimulation of auditory areas in a minipig model of electroacoustic cochlear implant. |
| Selected publications |
Investigating the sub-threshold spectrum of food addiction in relationship with impairment and distress: a dimensional analysis in patients with severe obesity. Constant, A., Som, M., Val-Laillet, D., Moirand, R., Thibault, R. 2024. Journal of Addictive Diseases. IF 2.065
The Yucatan minipig model: a new preclinical model of malnutrition in obese patients with acute or chronic diseases. Couvert, A., Lacaze, L., Touboulic, S., Gautier, S., Guérin, S., Randuineau, G., Romé, V., Malbert, C.H., Val-Laillet, D., Derbré, F., Ronan Thibault. Clinical Nutrition. DOI:10.1016/j.clnu.2023.12.003. IF 7.045
Hypothermic machine perfusion preservation: A proof of concept for uterus transplantation. Dion, L., Sousa, C., Boudjema, K. Val-Laillet, D., Jaillard, S., Rioux-Leclercq, N., Flecher, E., Lavoué, V. 2023. Fertility and Sterility, 120 (6). DOI:10.1016/j.fertnstert.2023.08.020. IF 7.490
Development of a functional dairy snack containing oleoylethanolamide than reduces food intake in normal-weight and obese minipigs. Boudry, G., Mennella, I., Menard, O., Janvier, R., Nogret, I., Madadlou, A., Cahu, A., Le Normand, L., Bobillier-Chaumont, E., Ferracane, R., Vitaglione, P., Dupont, D., Val-Laillet, D. 2023. Journal of Functional Foods, 111, 105916. DOI:10.1016/j.jff.2023.105916. IF 5.223
Emotional overeating affected nine in ten female students during the COVID-19 University closure: A cross-sectional study in France. Constant, A., Fortier, A., Serrand, Y., Bannier, E., Moirand, R., Thibault, R., Coquery, N., Godet, A., Val-Laillet, D. 2023. PLoS ONE 18(8): e0286439. DOI: 10.1371/journal.pone.0286439. IF 3.752
Subjective feeling of control during fNIRS-based neurofeedback targeting the DL-PFC is related to neural activation determined with short-channel correction. Godet, A., Serrand, Y., Fortier, A., Léger, B., Bannier, E., Val-Laillet, D., Coquery, N. 2023. PLoS ONE. 18(8):e0290005. eCollection 2023. PMID: 37585456. DOI: 10.1371/journal.pone.0290005. IF 3.752
Exposure to a sensory functional ingredient in the pig model modulates the blood-oxygen-level dependent brain responses to food odor and acute stress during pharmacological MRI in the frontostriatal and limbic circuits. Briard, E., Serrand, Y., Dahirel, P., Janvier, R., Noirot, V., Etienne, P., Coquery, N., Eliat, P.A., Val-Laillet, D. 2023. Frontiers in Nutrition. DOI: 10.3389/fnut.2023.1123162. IF 6.590
Exploration of fMRI brain responses to oral sucrose stimulation after Roux-en-Y gastric bypass in obese Yucatan minipigs in relationship with microbiota and metabolomic profiles using integrative analysis with co-expression network analysis. Bergeat, D., Coquery, N., Gautier, Y., Clotaire, S., Vincent, E., Romé, V., Guérin, S., Le Huërou-Luron, I., Blat, S., Thibault, R., Val-Laillet, D. 2023. Clinical Nutrition. DOI: 10.1016/j.clnu.2023.01.015. IF 7.045
Interactions between emotions and eating behaviors: Main issues, neuroimaging contributions, and innovative preventive or corrective strategies. Godet, A., Fortier, A., Bannier, E., Coquery, N., Val-Laillet, D. 2022. Reviews in Endocrine and Metabolic Disorders. DOI: 10.1007/s11154-021-09700-x. IF 5.516
High visceral fat is associated with lower overall and disease-free survivals after curative liver resection for intrahepatic cholangiocarcinoma. Lacaze, L., Bergeat, D., Merdrignac, A., Rousseau, C., Sulpice, L., Val-Laillet, D., Boudjema, K., Thibault, R. 2022. Nutrition and Cancer. 75(1):339-348. DOI: 10.1080/01635581.2022.2117387. IF 3.095
Acute effects of different electroacupuncture point combinations to modulate the gut-brain-axis in the minipig model. Zhang, X., Guérin, S., Launay, Y., Serrand, Y., Coquery, N., Val-Laillet, D. 2022. Eating and Weight Disorders. 2022:4384693. DOI: 10.1155/2022/4384693. IF 4.652.
The Yucatan minipig model: A new experimental approach to explore low-calorie/low-protein diet-induced sarcopenia. Lacaze, L., Rochdi, S., Couvert, A., Touboulic, S., Guérin, S., Randuineau, G., Martin, D., Romé, V., Malbert, C.H., Derbré, F., Val-Laillet, D.#, Thibault, R.# 2022. Clinical Nutrition. 41(10):2077-2086. DOI: 10.1016/j.clnu.2022.08.002. IF 7.045
Brain responses to food choices and decisions depend on individual hedonic profiles and eating habits in healthy young women. Coquery, N., Gautier, Y., Serrand, Y., Meurice, P., Bannier, E., Thibault, R., Constant, A., Moirand, R., Val-Laillet, D. 2022. Frontiers in Nutrition / Nutrition, Psychology and Brain Health. DOI: 10.3389/fnut.2022.920170. IF 6.590
Le régime occidental, l’obésité et la chirurgie bariatrique modulent l’anxiété, les habitudes alimentaires et la réponse cérébrale au goût sucré. Gautier, Y., Bergeat, D., Serrand, Y., Réthoré, N., Mahérault, M., Malbert, C.H., Meurice, P., Coquery, N., Moirand, R., Val-Laillet, D. 2022. Medecine Sciences, 38:125-151. DOI: 10.1051/medsci/2021252.
Obesity animal models for acupuncture and related therapy researches. Zhang, X., Val-Laillet, D. 2021. Evidence-Based Complementary and Alternative Medicine. Volume 2021, Article ID 6663397. DOI: 10.1155/2021/6663397. IF 2.629
A pilot study about the development and characterization of a Roux-en-Y gastric bypass model in obese Yucatan minipigs. Bergeat, D., Blat, S., Guérin, S., Le Huërou-Luron, I., Thibault, R., Val-Laillet, D. 2021. Scientific Reports, 11:20190. DOI: 10.1038/s41598-021-98575-8. IF 4.996
Food addiction among morbidly obese patients: Prevalence and links with obesity complications. Som, M., Constant, A., Zayani, T., Le Pabic, E., Moirand, R., Val-Laillet, D., Thibault, R. 2021. J Addic Dis, Jun 14;1-8. DOI: 10.1080/10550887.2021.1939630. IF 1.762
Contrasted central effects of n-3 versus n-6 diets on brain functions in diet-induced obesity in minipigs. Malbert, C.H., Val-Laillet, D., Meurice, P., Lallès, J.P., Delarue, J. 2021. Nutritional Neuroscience. DOI: 10.1080/1028415X.2020.1866881. IF 5.000
Single bilateral ovarian venous return in uterine transplant: Validation in an orthotopic auto-transplant model in the Yucatan minipig. Dion, L., Le Lous, M., Nyangoh Timoh, K., Levêque, J., Arnaud, A., Malbert, C.H., Foucher, F., Boudjema, K., Bendavid, C., Vigneau, C., Legembre, P., Val-Laillet, D., Lavoué, V. 2021. J Gynecol Obstet Hum Reprod, 50(7):102059. DOI: 10.1016/j.jogoh.2021.102059. IF 1.910
Meeting of minds around food addiction: Insights from addiction medicine, nutrition, psychology, and neurosciences. Constant, A., Moirand, R., Thibault, R., Val-Laillet, D. 2020. Nutrients, 12(11):3564. DOI: 10.3390/nu12113564. IF 5.719
Hypothesis paper: Electroacupuncture targeting the gut-brain axis to modulate neurocognitive determinants of eating behaviour – Toward a proof of concept in the obese minipig model. Zhang, X., Chen, H.W., Val-Laillet, D. 2020. Eating and Weight Disorders – Studies on Anorexia Bulimia and Obesity, 26(1):61-74. DOI: 10.1007/s40519-020-00864-0. IF 4.652
Western diet, obesity and bariatric surgery sequentially modulated anxiety, eating patterns and brain responses to sucrose in adult Yucatan minipigs. Gautier, Y., Bergeat, D., Serrand, Y., Réthoré, N., Mahérault, M., Malbert, C.H., Meurice, P., Coquery, N., Moirand, R., Val-Laillet, D. 2020. Scientific Reports, 10(1):20130. DOI: 10.1038/s41598-020-76910-9. IF 4.996
Query response: The importance of adequate oxygenation during hypothermic machine perfusion. Val-Laillet, D., Ben Mosbah, I., Corlu, A., Boudjema, K. 2020. Journal of Hepatology Reports, 3(1):100216. DOI: 10.1016/j.jhepr.2020.100216. IF 9.917
A maternal Western diet during gestation and lactation modifies offspring’s microglial cell density and morphology in the hippocampus and prefrontal cortex in Yucatan minipigs. Val-Laillet, D., Kanzari, A., Guérin, S., Randuineau, G., Coquery, N. 2020. Neurocience Letters, 739:135395. DOI: 10.1016/j.neulet.2020.135395. IF 3.046
Addition of the oxygen carrier M101 to a cold storage solution as an alternative to hypothermic oxygenated machine perfusion to improve pig liver grafts preservation. Alix, P., Val-Laillet, D., Turlin, B., Benmosbah, I., Burel, A., Bobillier, E., Bendavid, C., Delpy, E., Zal, F., Corlu, A., Boudjema, K. 2020. Journal of Hepatology Reports, 2(4):100119. DOI: 10.1016/j.jhepr.2020.100119. IF 9.917
Regular exposure to a Citrus-based sensory functional ingredient alleviates the BOLD brain responses to acute pharmacological stress in a pig model of psychosocial chronic stress. Menneson, S., Serrand, Y., Janvier, R., Noirot, V., Etienne, P., Coquery, N., Val-Laillet, D. 2020. PLoS ONE, 10.1371. DOI: 10.1371/journal.pone.0243893. IF 3.752
Neuromodulatory and possible anxiolytic-like effects of a spice functional food ingredient in a pig model of psychosocial chronic stress. Menneson, S., Ménicot, S., Malbert, C.-H., Meurice, P., Serrand, Y., Noirot, V., Etienne, P., Coquery, N., Val-Laillet, D. 2020. Journal of Functional Foods, 64, 103599 p. DOI: https://doi.org/10.1016/j.jff.2019.103599. IF 5.223
Apport de l’imagerie cérébrale pour étudier les préférences alimentaires. Val-Laillet, D. 2019. Réalités Pédiatriques, octobre 2019.
Impact of food, gut-brain signals, and metabolic status on brain activity in the pig model: 10 years of nutrition research using in vivo brain imaging. Val-Laillet, D. 2019. Animal. 13(11):2699-2713. DOI: 10.1017/S1751731119001745. IF 3.266
Ethanolamine produced from oleoylethanolamide degradation contributes to acetylcholine/dopamine balance modulating eating behavior. Mennella, I., Boudry, G., Val-Laillet, D. 2019. The Journal of Nutrition, 149(3):362-365. DOI: 10.1093/jn/nxy281. IF 4.281
Implementation of a new food picture database for validating a pilot fMRI cognitive food-choice task in healthy volunteers with contrasted eating habits. Gautier, Y., Meurice, P., Coquery, N., Constant, A., Bannier, E., Ferré, J.C., Moirand, R., Val-Laillet, D. 2019. Frontiers in Psychology, 10:2620. DOI: 10.3389/fpsyg.2019.02620. IF 4.232
Locomotion and eating behavior changes in Yucatan minipigs after unilateral radio-induced ablation of the caudate nucleus. Coquery, N., Adam, J.F., Nemoz, C., Janvier, R., Livingstone, J., Chauvin, A., Kefs, S., Guérineau, C., De Saint Jean, L., Ocadiz, A., Bouchet, A., Bartzsch, S., Schültke, E., Siegbahn, A., Bräuer-Krisch, E., Lemasson, B., Barbier E.L., Laissue, J., Balosso, J., Val-Laillet, D., Serduc, R. 2019. Scientific Reports, 9(1):17082. DOI: 10.1038/s41598-019-53518-2. IF 4.996
Depressive symptoms are related to Boredom Proneness in patients receiving hospital care, regardless of alcohol status, lifestyle or social support. Constant, A., Val-Laillet, D., Joubert, A., Foret, K., Thibault, R., Moirand, R. 2019. Journal of Health Psychology, 8:1359105319886049. DOI: 10.1177/1359105319886049. IF 3.231
fMRI-based brain responses to olfactory stimulation with two putatively orexigenic food additives at two different concentrations in the pig model. Coquery, N., Menneson, S., Meurice, P., Janvier, R., Etienne, P., Noirot, V., Val-Laillet, D. 2019. Journal of Food Science, 84(9):2666-2673. DOI: 10.1111/1750-3841.14772. IF 3.167
Validation of a psychosocial chronic stress model in the pig using a multidisciplinary approach at the gut-brain and behavior levels. Menneson, S., Ménicot, S., Ferret-Bernard, S., Guérin, S., Romé, V., Le Normand, L., Randuineau, G., Gambarota, G., Noirot, V., Etienne, P., Coquery, N., Val-Laillet, D. 2019. Frontiers in Behavioural Neuroscience. 13:161. DOI: 10.3389/fnbeh.2019.00161. IF 3.104
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