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| Nom | Sandrine DAVID-LE GALL |
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| Adresse | 2 av du Pr Léon Bernard 35043 Rennes CEDEX |
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| Skills | Microbiota analysis genomic proteomic molecular biology cellular Biology anaerobic and aerobic bacteria culture Gene cloning, Construction of mutant strains Microarrays , analysis of genes and genomes Production of recombinant protein via a pQE 30-UA system Proteomic analysis : extraction and purification of proteins , SDS-PAGE gels, 2D gels, flow cytometry. ELISA
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| Research topics and scientific objectives | My objective, which fits into this framework, is to clarify the links that exist between pathologies of iron metabolism, including iron overload, and modulations of the intestinal microbiota. |
| Education and main positions held | PhD in health science, Faculty of Pharmacy, University of de Rennes 1, France, in Microbiology laboratory EA 1254 « Infectious risks », Subject: “ Isolation, genetic characterization of a hypermutator strain of Salmonella and study of its adaptability to acidic stress. Associated Professor in microbiology, Faculty of Pharmacy, University of de Rennes 1
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| Current projects | Recruited as a teacher-researcher at the University of Rennes I on September 1, 2017, I carry out my teaching activity at the UFR of Pharmacy in the field of microbiology and my research activity within the UMR INSERM/ UR1 1241, from the NUMECAN Institute. This research activity is part of the theme of the METHER team, which studies the links between iron metabolism, human health, and the development of pathologies. My objective, which fits into this framework, is to clarify the links that exist between pathologies of iron metabolism, including iron overload, and modulations of the intestinal microbiota. At the same time, I am setting up a “eubiotic” or commensal bacterial community by bringing together several so-called non-pathogenic bacterial species in order to eventually be able to place them in contact with a complex intestinal cell model developed in the laboratory (Latifa Bousarghin). The choice of bacteria was made based on the analysis of our microbiota and the literature. This model of intestinal epithelium supplemented with intestinal commensal bacteria will closely mimic the intestinal barrier. This model will allow us to study the impact of bacteria identified during the study of microbiota. |
| Selected publications | Increased transferrin saturation is associated with subgingival microbiota dysbiosis and severe periodontitis in genetic haemochromatosis. Boyer E, Le Gall-David S, Martin B, Fong SB, Loréal O, Deugnier Y, Bonnaure-Mallet M, Meuric V. Sci Rep. 2018 Oct 19;8(1):15532. doi: 10.1038/s41598-018-33813-0. PMID: 30341355 Free PMC article.
Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response. Blasco-Baque V, Garidou L, Pomié C, Escoula Q, Loubieres P, Le Gall-David S, Lemaitre M, Nicolas S, Klopp P, Waget A, Azalbert V, Colom A, Bonnaure-Mallet M, Kemoun P, Serino M, Burcelin R. Gut. 2017 May;66(5):872-885. doi: 10.1136/gutjnl-2015-309897. Epub 2016 Feb 2. PMID: 26838600 Free PMC article.
Le Gall-David, S., V. Meuric, G. Benzoni, S. Valière, A. Guyonvarch, J. Minet, M. Bonnaure-Mallet and F. Barloy-Hubler (2017). « Effect of Zeolite on Small Intestine Microbiota of Broiler Chickens: A Case Study. » Food and Nutrition Sciences 8: 163-188. Hypermutator Salmonella Heidelberg induces an early cell death in epithelial cells. Le Gall-David S, Zenbaa N, Bouchard D, Lavault MT, Bonnaure-Mallet M, Jolivet-Gougeon A, Bousarghin L. Vet Microbiol. 2015 Oct 22;180(1-2):65-74. doi: 10.1016/j.vetmic.2015.07.034. Epub 2015 Aug 5. PMID: 26320605 Maternal Linoleic Acid Overconsumption Alters Offspring Gut and Adipose Tissue Homeostasis in Young but Not Older Adult Rats. Marchix J, Alain C, David-Le Gall S, Acuña-Amador LA, Druart C, Delzenne NM, Barloy-Hubler F, Legrand P, Boudry G. Nutrients. 2020 Nov 11;12(11):3451. doi: 10.3390/nu12113451. PMID: 33187208 Free PMC article |