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["Investigateur responsable","Equipe","Saisine","N° Apafis","Date acceptation du projet par le ministère","Acronyme expérimentation","Fournisseur","Nom animalerie","Espèce","Lignée","Génotype","Sexe","âge début d'expérimentation","Nombre d'animaux","Mot clé pathologie ","Mot clé molécule","Méthode de traitement","Alimentation/Traitement spécifique ","Durée de l'expérimentation","Prélèvement intermédiaire (sang, organe…)","Date de mise à mort","Méthode mise à mort","Heure","Âge à la date de mise à mort","liquide nature , Contenu (liquide/selle)","Organes Congelés","Organes inclus","Donné à, le"]
["François Robin","METHER","Caractérisation des mécanismes cellulaires et moléculaires\nimpliqués dans le développement de l’ostéopathie induite par\nle méthotrexate (MTX) : évaluation des conséquences\nosseuses chez la souris",48283,"2024-04-27",null,"Janvier Labs","M2S","SOURIS","C57BL/6J","sauvage","MÂLE","8 semaines",20,"Métaux, Minéralisation, Inflammation, Ostéoporose","Méthotrexate","Intrapéritonéale","Méthotrexate","8 semaines",null,"2024-11-06","isoflurane, Dislocation cervicale",null,"16 semaines",null,"Côlon, Duodénum, jejunum, Foie, Rate, Rein, Tête","Côlon, Duodénum, jejunum, Foie, Rate, Rein, Tête","Annaïg a fait des prélèvements: colon, duo, jejunum"]
["Karima Begriche","Expres","Rôle du CYP2E1 dans la physiopathologie de la stéatose\nd'origine métabolique et/ou médicamenteuse chez la souris","23966-2020013110482961 v3"," 27/06/2020 ","LipoNASH- étude 2","Janvier Labs","Arche- Biosit","souris","C57BL/6J","sauvage","MÂLE","6 semaines",null,"NAFLD, obésité, hépatotoxicité","paracétamol, acide linoléique, acide linolénique","Nutrition","régime normolipidique (10%) ou hyperlipidique (45%) - Paracétamol per os à doses thérapeutiques (500 mg/kg poids/jour)","16 semaines","plasma à 2 mois (nourri et à jeun)","4 et 5 /03/2021 et 11 et 12/03/2021  (après jeûne nocturne)",null,"9h à 12h (matinée)","6 mois","plasma ","Foie, muscle, tissus adipeux (épididymal et inguinal), pancréas","Foie, tissus adipeux épididymal et brun, pancréas "]
["Olivier loréal","METHER","Identification de signatures et optimisation des procédures d’analyse de profils métaboliques et métallomiques dans un modèle souris.","21298-201906191539232","2019-11-22","DPS-Met","Janvier/abs","Arche- Biosit","SOURIS","C57BL/6J","sauvage","MÂLE"," régime alimentaire : 18/12/2019 et injection fer/dextran: 6-7/01/2020",100,"stéatohépatite","Métaux, Acides gras","Injection, Nutrition","D12328;       10 kcal% fat; Research Diets, New Brunswick, NJ, D12331;       58 kcal% fat diet, Fer , 55% fructose and 45% sucrose: at a concentration of 42 g L","5 mois","sérum","18/05/2020 au 03/06/2020","isoflurane","9h à 12h ","6 mois","sérum, urine, sang","Foie, Rate, Rein, Duodénum, Cœur, Caecum, Pancréas, Microbiote, Os","Cerveau, Cœur, Foie, Rate, Rein, Duodénum, Cœur, Caecum, Pancréas, Microbiote, Os"]

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["Equipe","Espèce","Sexe","Fournisseurs","Nom animalerie","Traitement","Mot clé Pathologie ","Mot clé molécule"," Méthode traitement","Organes Congelés","Organes inclus","liquide nature ","Méthode d'euthanasie"]
["EAT","PORC","FEMELLE","Biosit","Arche- Biosit","Acides gras","Addiction","Acides gras","Allaitement","Caecum","Caecum","féces","Décapitation"]
["EXPRESS","RAT ","MÂLE","Charles Rivers","M2S","Alcool","Atteinte cardiovasculaire","Alcool","Gavage","Cerveau","Cerveau","plasma ","Dioxyde de carbone"]
["METHER","SOURIS",null,"Envigo","UE3P","Autre","Cancer","Autre","Injection","Cœur","Cœur","sang total","Dislocation cervicale"]
[null,null,null,"Janvier/abs",null,"Bactérie","CHC","Bactérie","Intrapéritonéale","Côlon","Côlon","sérum","isoflurane"]
[null,null,null,null,null,"Fer ","Colite","Fer ","Nutrition","Duodénum","Duodénum","urine","Surdose d'anesthésique"]
[null,null,null,null,null,"Hypercalorique","Comportement","Hypercalorique","Sous cutanée","Féces","Fécès"]
[null,null,null,null,null,"LPS","Fibrose","LPS",null,"Foie","Foie"]
[null,null,null,null,null,"Métal","Inflammation","Métal",null,"Gras","Gras"]
[null,null,null,null,null,"Métalloprotéase","Inflammation","Métalloprotéase",null,"Iléon","Iléon"]
[null,null,null,null,null,"Métaux","Lipides","Métaux",null,"jejunum","jejunum"]
[null,null,null,null,null,"Valproate","Métabolisme","Valproate",null,"Microbiote","Microbiote"]
[null,null,null,null,null,"D12328;       10 kcal% fat; Research Diets, New Brunswick, NJ","Métaux",null,null,"Muscle","Muscle"]
[null,null,null,null,null,"D12331;       58 kcal% fat diet","Microbiote",null,null,"Os","Os"]
[null,null,null,null,null,"55% fructose and 45% sucrose: at a concentration of 42 g L","Minéralisation",null,null,"Ovaire ","Ovaire "]
[null,null,null,null,null,null,"Minéralisation",null,null,"Pancréas","Pancréas"]
[null,null,null,null,null,null,"NASH",null,null,"Plasma","Poumon"]
[null,null,null,null,null,null,"Neurologie",null,null,"Poumon","Rate"]
[null,null,null,null,null,null,"Ophtalmologie",null,null,"Rate","Rein"]
[null,null,null,null,null,null,"Ostéoporose",null,null,"Rein","Testicule"]
[null,null,null,null,null,null,"Parodontite",null,null,"Sang","Tissu adipeux viscéral"]
[null,null,null,null,null,null,"PXE",null,null,"Sérum","Yeux"]
[null,null,null,null,null,null,"Régénération",null,null,"Testicule"]
[null,null,null,null,null,null,"Remodelage",null,null,"Tissu adipeux viscéral"]
[null,null,null,null,null,null,"stéatohépatite",null,null,"Urine "]
[null,null,null,null,null,null,"Toxicité",null,null,"Yeux"]
[null,null,null,null,null,null,"Vectorisation"]
[null,null,null,null,null,null,"Xénobiotique"]