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CHU Pontchaillou – 2 rue Henri Le Guilloux – 35033 Rennes Cedex


Synthesis and characterization of biocompatible (co)polymer; Formulation and characterization of biocompatible nanoparticles formulation; Encapsulation of active molecules and characterization of active molecules-loaded nanoparticles.

Research topics and scientific objectives

Anionic ring-opening polymerization of b-substituted b-lactones in presence of functional initiators; Synthesis of poly(malic acid) derivatives; Chemical modifications; Functionalized (co)polyesters carrying molecules of interest (targeting agents, drugs, therapeutic genes, fluorescence probes, radionuclides, peptides, etc.); Characterizations of (co)polymers; Self-assembly of hydrophobic polymers and amphiphilic copolymers; Development of multifunctional biocompatible nanoparticles for therapy and/or diagnosis; Application in the context of hepatocellular carcinoma (HCC)

Education and main positions held

1989: Diploma of Chemical Engineer from the « Ecole Nationale Supérieure de Chimie de Rennes » (ENSCR) – France.

1990: Master II of Macromolecular Chemistry – University « Pierre et Marie Curie » (Paris VI) – Paris, France.

07/07/1993: PhD – University « Pierre et Marie Curie » (Paris VI) – Paris, France.

1993-1994: Post-doctorant, Science University of Tokyo – Japan.

1994-1995: Research Assistant Professor, Tokyo Women’s Medical College – Japan

1995-2000: CNRS researcher, UMR 7581 CNRS, France.

2000-2003: CNRS researcher, UMR 8612 CNRS, France.

2003-2005: CNRS researcher, UMR 6509 CNRS, France.

2005-2016: CNRS Researcher, ISCR UMR 6226 CNRS, National School of Chemistry of Rennes.

10/23/2007: « Habilitation à Diriger des Recherches », University of Rennes 1, UMR 6226 CNRS, ENSCR, “Design of degradable polymers and formulation of drug delivery systems.”

Since January 2017: CNRS researcher (CRHC), ISCR UMR 6226 CNRS, National School of Chemistry of Rennes. (50%) and NuMeCan Institute, U-1241 Inserm – INRA – University of Rennes 1 (50%).

“Degradable and biocompatible nano-platforms for therapy and/or diagnosis: From the design of molecular and macromolecular materials to in vitro and in vivo assays.”

Selected publications

“Natural and synthetic poly(malic acid)-based derivates: A family of versatile biopolymers for the design of drug nanocarriers.” Sandrine Cammas-Marion, Pascal Loyer, Journal of Drug Targeting, 22(7), 556-575, 2014.

In vitro Toxicity Evaluation and in vivo Biodistribution of Polymeric Micelles Derived from Poly(ethylene glycol)-b-poly(benzyl malate) Copolymers.” Elise Vene, Kathleen Jarnouen, Zhi Wei Huang, Bedhouche Wahib, Tristan Montier, Sandrine Cammas-Marion, Pascal Loyer. Pharmaceutical Nanotechnology, 4, 24-37, 2016.

“Poly(malic acid) bearing Doxorubicin and N-Acetyl Galactosamine as a site-specific prodrugs for targeting HepatoCellular Carcinoma.” Nivishna Venkatraj, M.J. Nanjan, Pascal Loyer, M.J.N. Chandrashekar, Sandrine Cammas-Marion. Journal of Biomaterials Science: Polymer Edition, 28 (10–12), 1140-1157, 2017.

“Cell Uptake and Biocompatibility of Nanoparticles Prepared from Poly(benzyl malate) (Co)polymers Obtained through Chemical and Enzymatic Polymerization in Human HepaRG Cells and Primary Macrophages.” H. Casajus, S. Saba, M. Vlach, E. Vène, C. Ribault, S. Tranchimand, C. Nugier-Chauvin, E. Dubreucq, P. Loyer, S. Cammas-Marion, N. Lepareur. Polymers, 10, 1244; 2018.

“Synthesis of Poly(Malic Acid) Derivatives End-Functionalized with Peptides and Preparation of Biocompatible Nanoparticles to Target Hepatoma Cells.” Clarisse Brossard, Manuel Vlach, Elise Vène, Catherine Ribault, Vincent Dorcet, Nicolas Noiret, Pascal Loyer, Nicolas Lepareur, Sandrine Cammas-Marion. Nanomaterials. 11, 958, 2021.

“Circumsporozoite protein of Plasmodium berghei- and George Baker Virus A-derived peptides trigger efficient cell internalization of bioconjugates and functionalized poly(ethylene glycol)-b-poly(benzyl malate)-based nanoparticles in human hepatoma cells.” Elise Vène, Kathleen Jarnouen, Catherine Ribault, Manuel Vlach, Yann Verres, Mickaël Bourgeois, Nicolas Lepareur, Sandrine Cammas-Marion, Pascal Loyer. Pharmaceutics “Special Issue Peptide-Based Drugs for Cancer Therapies.” 14, 804, 2022.

“Gallium-68 and Copper-64 radiolabelling of hepatotropic GBVA10-9 or CPB peptide derivatives for hepatocellular carcinoma imaging.” Clarisse Brossard, Mickaël Bourgeois, Sébastien Gouard, Christelle Bouvry, Elise Vène, Hanadi Nahas, Michel Chérel, Pascal Loyer, Sandrine Cammas-Marion, Nicolas Lepareur. Nuclear Medicine and Biology, 108, S153, 2022.